M-SYNTH is organized into a directory structure that indicates the parameters. Code and dataset is released with the Creative Commons 1.0 Universal License We now review the timing required to perform mass insertion and imaging. In Table 2, we review the imaging time required for each breast density. The time varies from 2.84 GPU), we were able to generate the complete dataset in about two weeks.Breast Density Time (min) Fatty 13.463809 Scattered 11.002291 Hetero 3.655613 Dense 2.842028 Table 2: Timing analysis for imaging by breast density. Additional renderings of the breast phantoms generated for the study are shown in Figure 1, demonstrating a high level of detail and anatomical variability within and among models.

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Precise mass location and extent (e.g., mass boundaries) are typically not available in the patient's records, and it is burdensome, error-prone, and sometimes impossible to

M-SYNTH is organized into a directory structure that indicates the parameters. Code and dataset is released with the Creative Commons 1.0 Universal License We now review the timing required to perform mass insertion and imaging. In Table 2, we review the imaging time required for each breast density. The time varies from 2.84 GPU), we were able to generate the complete dataset in about two weeks.Breast Density Time (min) Fatty 13.463809 Scattered 11.002291 Hetero 3.655613 Dense 2.842028 Table 2: Timing analysis for imaging by breast density. Additional renderings of the breast phantoms generated for the study are shown in Figure 1, demonstrating a high level of detail and anatomical variability within and among models.

Purpose: Explainability features are intended to provide insight into the internal mechanisms of an AI device, but there is a lack of evaluation techniques for assessing the quality of provided explanations. We propose a framework to assess and report explainable AI features. Materials and Methods: Our evaluation framework for AI explainability is based on four criteria: 1) Consistency quantifies the variability of explanations to similar inputs, 2) Plausibility estimates how close the explanation is to the ground truth, 3) Fidelity assesses the alignment between the explanation and the model internal mechanisms, and 4) Usefulness evaluates the impact on task performance of the explanation. Finally, we developed a scorecard for AI explainability methods that serves as a complete description and evaluation to accompany this type of algorithm. Results: We describe these four criteria and give examples on how they can be evaluated. As a case study, we use Ablation CAM and Eigen CAM to illustrate the evaluation of explanation heatmaps on the detection of breast lesions on synthetic mammographies. The first three criteria are evaluated for clinically-relevant scenarios. Conclusion: Our proposed framework establishes criteria through which the quality of explanations provided by AI models can be evaluated. We intend for our framework to spark a dialogue regarding the value provided by explainability features and help improve the development and evaluation of AI-based medical devices.

Leveraging large language models (LLMs) to generate high-stakes documents, such as informed consent forms (ICFs), remains a significant challenge due to the extreme need for regulatory compliance and factual accuracy. Here, we present InformGen, an LLM-driven copilot for accurate and compliant ICF drafting by optimized knowledge document parsing and content generation, with humans in the loop. We further construct a benchmark dataset comprising protocols and ICFs from 900 clinical trials. Experimental results demonstrate that InformGen achieves near 100% compliance with 18 core regulatory rules derived from FDA guidelines, outperforming a vanilla GPT-4o model by up to 30%. Additionally, a user study with five annotators shows that InformGen, when integrated with manual intervention, attains over 90% factual accuracy, significantly surpassing the vanilla GPT-4o model's 57%-82%. Crucially, InformGen ensures traceability by providing inline citations to source protocols, enabling easy verification and maintaining the highest standards of factual integrity.

Interpretability is critical for machine learning models in high-stakes settings because it allows users to verify the model's reasoning. In computer vision, prototypical part models (ProtoPNets) have become the dominant model type to meet this need. Users can easily identify flaws in ProtoPNets, but fixing problems in a ProtoPNet requires slow, difficult retraining that is not guaranteed to resolve the issue. This problem is called the "interaction bottleneck." We solve the interaction bottleneck for ProtoPNets by simultaneously finding many equally good ProtoPNets (i.e., a draw from a "Rashomon set"). We show that our framework - called Proto-RSet - quickly produces many accurate, diverse ProtoPNets, allowing users to correct problems in real time while maintaining performance guarantees with respect to the training set. We demonstrate the utility of this method in two settings: 1) removing synthetic bias introduced to a bird identification model and 2) debugging a skin cancer identification model. This tool empowers non-machine-learning experts, such as clinicians or domain experts, to quickly refine and correct machine learning models without repeated retraining by machine learning experts.

With the advent of large multimodal language models, science is now at a threshold of an AI-based technological transformation. Recently, a plethora of new AI models and tools has been proposed, promising to empower researchers and academics worldwide to conduct their research more effectively and efficiently. This includes all aspects of the research cycle, especially (1) searching for relevant literature; (2) generating research ideas and conducting experimentation; generating (3) text-based and (4) multimodal content (e.g., scientific figures and diagrams); and (5) AI-based automatic peer review. In this survey, we provide an in-depth overview over these exciting recent developments, which promise to fundamentally alter the scientific research process for good. Our survey covers the five aspects outlined above, indicating relevant datasets, methods and results (including evaluation) as well as limitations and scope for future research. Ethical concerns regarding shortcomings of these tools and potential for misuse (fake science, plagiarism, harms to research integrity) take a particularly prominent place in our discussion. We hope that our survey will not only become a reference guide for newcomers to the field but also a catalyst for new AI-based initiatives in the area of "AI4Science".

Medical imaging systems are commonly assessed and optimized by the use of objective measures of image quality (IQ). The performance of the ideal observer (IO) acting on imaging measurements has long been advocated as a figure-of-merit to guide the optimization of imaging systems. For computed imaging systems, the performance of the IO acting on imaging measurements also sets an upper bound on task-performance that no image reconstruction method can transcend. As such, estimation of IO performance can provide valuable guidance when designing under-sampled data-acquisition techniques by enabling the identification of designs that will not permit the reconstruction of diagnostically inappropriate images for a specified task - no matter how advanced the reconstruction method is or how plausible the reconstructed images appear. The need for such analysis is urgent because of the substantial increase of medical device submissions on deep learning-based image reconstruction methods and the fact that they may produce clean images disguising the potential loss of diagnostic information when data is aggressively under-sampled. Recently, convolutional neural network (CNN) approximated IOs (CNN-IOs) was investigated for estimating the performance of data space IOs to establish task-based performance bounds for image reconstruction, under an X-ray computed tomographic (CT) context. In this work, the application of such data space CNN-IO analysis to multi-coil magnetic resonance imaging (MRI) systems has been explored. This study utilized stylized multi-coil sensitivity encoding (SENSE) MRI systems and deep-generated stochastic brain models to demonstrate the approach.